Athina Christina Georgiou
Academic Centre Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands
The contribution of apical periodontitis to systemic chronic inflammation and the role of the endodontic infection in the inflammatory response.
AWARD: 40,000 Euros


Roda Seseogullari Dirihan
Institute of Dentistry, University of Turku, Finland
Optimization of Dentin-Pulp Regeneration by Using a Smart Multilayer Scaffold
AWARD: 20,000 Euros

Sadia Ambreen Niazi
King’s College London, Dental Institute, UK
Endodontic infection-Mediated systemic interactions pose global cardiometabolic risk
AWARD: 20,000 Euros


Phillip Tomson
The University of Birmingham School of Dentistry, Birmingham, UK
High quality obturation simplified – is it possible? An investigation of the single cone technique used with hydraulic calcium silicate-based materials
Award: 20,000 Euros

Christos Boutsioukis
ACTA, Amsterdam, The Netherlands
Irrigation in minimally-shaped root canals
Award: 20,000 Euros

Publication: Boutsioukis C, Gutierrez Nova P (2021) Syringe irrigation in minimally-shaped root canals using three endodontic needles: a Computational Fluid Dynamics study.
Journal of Endodontics In press (doi: 10.1016/j.joen.2021.06.001).


Lise-Lotte Kirkevang
Aarhus University, Denmark
Development in endodontic status in a general population. A repeated cohort study
Award: 20,000 Euros


Endodontic infections and systemic health

Pirkko Pussinen
University of Helsinki, Finland
Endodontic infections, inflammation, and coronary artery disease
Award: 40,000 Euros

Thomas Kvist
University of Gothenburg, Sweden
Do root fillings and apical periodontitis increase the risk of a first myocardial infarction
Award: 40,000 Euros


Maikel Vogels
ACTA, Amsterdam, The Netherlands
Treatment outcome of endodontically treated teeth with apical periodontitis: apical surgery or non-surgical endodontic retreatment
Award: 10,000 Euros

Hermann Agis
Medical University of Vienna, Vienna, Austria
Effect of hypoxia and hypoxia mimetic agents on sclerostin and dickkopf-1 production in dental pulp cells and tooth slice organ cultures
Award: 10,000 Euros
Publication: Janjić K, Cvikl B, Kurzmann C, Moritz A, Agis H (2018) Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures BMC Oral Health 18, 36 



Luc van der Sluis
Center for Dentistry and Oral Hygiene, University Medical Center Groningen (UMCG), Groningen, The Netherlands
A novel optical methodology for quantifying the removal of a biofilm from lateral morphological features of the root canal
Award: 20,000 Euros


Maria Pigg
Department of Endodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Prevalence of pain and discomfort from root-filled teeth.
Award: 8000 Euros 

Karin Huth
Department of Restorative Dentistry and Periodontology, University of Munich, Munich, Germany
Effectiveness of high concentrated ozone gas against periapical periodontitis – a randomized clinical trial
Award: 12000 Euros


Imad About
Université de la Méditerranée, Marseille, France
The pivotal role of complement activation in pulp progenitor cell migration after pulp injury and therapeutic application of pulp capping materials
Award: 10000 Euros
Publications: F. Chmilewsky, C. Jeanneau, P. Laurent, M. Kirschfink, I. About (2013) Pulp Progenitor Cell Recruitment is Selectively Guided by a C5a Gradient Journal of Dental Research 92, 532-9
F Chmilewsky, C Jeanneau, P Laurent, I About Pulp (2014) Fibroblasts Synthesize Functional Complement Proteins Involved in Initiating Dentine-Pulp Regeneration The American Journal of Oral Pathology 184,1991-2000
F. Chmilewsky, C. Jeanneau, P. Laurent, I. About (2015) LPS Induces Pulp Progenitor Cell Recruitment via Complement Activation Journal of Dental Research 94 166-74

Henry (Hal) Duncan
Dublin Dental University Hospital, Dublin, Ireland
Analysis of the ability of histone deacetylase inhibitors (HDACi) to solubilise bio-active dentine matrix proteins for promotion of tissue repair mechanisms.
Award: 10000 Euros
Publications: Duncan HF, Smith AJ, Fleming GJP, Moran GP, Cooper PR (2015) Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points. Genomics Data 5, 391-3. doi: 10.1016/j.gdata.2015.07.013. PMID: 26484294
Duncan HF, Smith AJ, Fleming GJP, Partridge NC, Shimizu E, Moran GP, Cooper PR (2016) The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity. Journal of Cellular Physiology 231, 798-816. doi: 10.1002/jcp.25128. PMID: 26264761
Duncan HF, Smith AJ, Fleming GP, Reid C, Smith G, Cooper PR (2016) Release of bio-active dentine extracellular matrix components by histone deacetylase inhibitors (HDACi) International Endodontic Journal. doi: 10.1111/iej.12588. [Epub ahead of print] PMID: 26609946
Duncan HF, Smith AJ, Fleming GP, Cooper PR (2016). Epigenetic modulation of dental pulp stem cells: implications for regenerative endodontics. International Endodontic Journal doi: 10.1111/iej.12475. [Epub ahead of print] PMID: 26011759


Kerstin Galler
University of Regensburg, Regensburg, Germany
Release if Growth Factors from Dentin and Incorporation into a Hydrogel Scaffold for Regenerative Endodontics
Award:18000 Euros
Publication: Galler KM, Widbiller M, Buchalla W, Eidt A, Hiller KA, Hoffer PC, Schmalz G (2015) EDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells. International Endodontic Journal doi: 10.1111/iej.12492. [Epub ahead of print]

Gianluca Gambarini
Universita' degli Studi di Roma, Rome, Italy
Biochemical characterization of dental pulp stem cells and effect of methylacrylate monomers on cell differentiation
Award: 10000 Euros
Publications: Nocca G, Ragno R, Carbone V, Martorana GE, Rossetti DV, Gambarini G, Giardina B, Lupi A. (2011) Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis. Dental Materials 27,e87-98.
Gambarini G, Plotino G, Grande NM, Nocca G, Lupi A, Giardina B, De Luca M, Testarelli L (2011) In vitro evaluation of the cytotoxicity of FotoSan™ light-activated disinfection on human fibroblasts. Medical Science Monitor 17, MT21-5.
Testarelli L; Nocca G, Lupi A; Pacifici G; Pompa G; Vozza I, Gambarini G (2012) Biocompatibility of root canal filling materials: differences between vitality and functionality tests. European Journal of Inflammation 10, 105-10.
Chronopoulou L, Nocca G, Castagnola M, Paludetti G, Ortaggi G, Sciubba F, Bevilacqua M, Lupi A, Gambarini G, Palocci C (2016) Chitosan based nanoparticles functionalized with peptidomimetic derivatives for oral drug delivery. New Biotechnology 33, 23-31 

Suzette van der Waal
Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands
How to disrupt biofilm matrix
Award: 10000 Euros
Publication: van der Waal S V, de Almeida J, Krom B P, de Soet J J, Crielaard W Diffusion of antimicrobials in multispecies biofilms evaluated in a new biofilm model DOI: 10.1111/iej.12634