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Annual Research Grant - Past Awards


Athina Christina Georgiou
Academic Centre Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands
The contribution of apical periodontitis to systemic chronic inflammation and the role of the endodontic infection in the inflammatory response.
AWARD: 40,000 Euros


Roda Seseogullari Dirihan
Institute of Dentistry, University of Turku, Finland
Optimization of Dentin-Pulp Regeneration by Using a Smart Multilayer Scaffold
AWARD: 20,000 Euros

Sadia Ambreen Niazi
King’s College London, Dental Institute, UK
Endodontic infection-Mediated systemic interactions pose global cardiometabolic risk
AWARD: 20,000 Euros


Phillip Tomson
The University of Birmingham School of Dentistry, Birmingham, UK
High quality obturation simplified – is it possible? An investigation of the single cone technique used with hydraulic calcium silicate-based materials
Award: 20,000 Euros

Christos Boutsioukis
ACTA, Amsterdam, The Netherlands
Irrigation in minimally-shaped root canals
Award: 20,000 Euros


Lise-Lotte Kirkevang
Aarhus University, Denmark
Development in endodontic status in a general population. A repeated cohort study
Award: 20,000 Euros

Endodontic infections and systemic health

Pirkko Pussinen
University of Helsinki, Finland
Endodontic infections, inflammation, and coronary artery disease
Award: 40,000 Euros

Thomas Kvist
University of Gothenburg, Sweden
Do root fillings and apical periodontitis increase the risk of a first myocardial infarction
Award: 40,000 Euros


Maikel Vogels
ACTA, Amsterdam, The Netherlands
Treatment outcome of endodontically treated teeth with apical periodontitis: apical surgery or non-surgical endodontic retreatment
Award: 10,000 Euros

Hermann Agis
Medical University of Vienna, Vienna, Austria
Effect of hypoxia and hypoxia mimetic agents on sclerostin and dickkopf-1 production in dental pulp cells and tooth slice organ cultures
Award: 10,000 Euros
Publication: Janjić K, Cvikl B, Kurzmann C, Moritz A, Agis H (2018) Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures BMC Oral Health 18, 36


Luc van der Sluis
Center for Dentistry and Oral Hygiene, University Medical Center Groningen (UMCG), Groningen, The Netherlands
A novel optical methodology for quantifying the removal of a biofilm from lateral morphological features of the root canal
Award: 20,000 Euros


Maria Pigg
Department of Endodontics, Faculty of Odontology, Malmö University, Malmö, Sweden
Prevalence of pain and discomfort from root-filled teeth.
Award: 8000 Euros

Karin Huth
Department of Restorative Dentistry and Periodontology, University of Munich, Munich, Germany
Effectiveness of high concentrated ozone gas against periapical periodontitis – a randomized clinical trial
Award: 12000 Euros


Imad About
Université de la Méditerranée, Marseille, France
The pivotal role of complement activation in pulp progenitor cell migration after pulp injury and therapeutic application of pulp capping materials
Award: 10000 Euros
Publications: F. Chmilewsky, C. Jeanneau, P. Laurent, M. Kirschfink, I. About (2013) Pulp Progenitor Cell Recruitment is Selectively Guided by a C5a Gradient Journal of Dental Research 92, 532-9
F Chmilewsky, C Jeanneau, P Laurent, I About Pulp (2014) Fibroblasts Synthesize Functional Complement Proteins Involved in Initiating Dentine-Pulp Regeneration The American Journal of Oral Pathology 184,1991-2000
F. Chmilewsky, C. Jeanneau, P. Laurent, I. About (2015) LPS Induces Pulp Progenitor Cell Recruitment via Complement Activation Journal of Dental Research 94 166-74

Henry (Hal) Duncan
Dublin Dental University Hospital, Dublin, Ireland
Analysis of the ability of histone deacetylase inhibitors (HDACi) to solubilise bio-active dentine matrix proteins for promotion of tissue repair mechanisms.
Award: 10000 Euros
Publications: Duncan HF, Smith AJ, Fleming GJP, Moran GP, Cooper PR (2015) Transcriptional profiling of suberoylanilide hydroxamic acid (SAHA) regulated genes in mineralizing dental pulp cells at early and late time points. Genomics Data 5, 391-3. doi: 10.1016/j.gdata.2015.07.013. PMID: 26484294
Duncan HF, Smith AJ, Fleming GJP, Partridge NC, Shimizu E, Moran GP, Cooper PR (2016) The histone-deacetylase-inhibitor suberoylanilide hydroxamic acid promotes dental pulp repair mechanisms through modulation of matrix metalloproteinase-13 activity. Journal of Cellular Physiology 231, 798-816. doi: 10.1002/jcp.25128. PMID: 26264761
Duncan HF, Smith AJ, Fleming GP, Reid C, Smith G, Cooper PR (2016) Release of bio-active dentine extracellular matrix components by histone deacetylase inhibitors (HDACi) International Endodontic Journal. doi: 10.1111/iej.12588. [Epub ahead of print] PMID: 26609946
Duncan HF, Smith AJ, Fleming GP, Cooper PR (2016). Epigenetic modulation of dental pulp stem cells: implications for regenerative endodontics. International Endodontic Journal doi: 10.1111/iej.12475. [Epub ahead of print] PMID: 26011759


Kerstin Galler
University of Regensburg, Regensburg, Germany
Release if Growth Factors from Dentin and Incorporation into a Hydrogel Scaffold for Regenerative Endodontics
Award:18000 Euros
Publication: Galler KM, Widbiller M, Buchalla W, Eidt A, Hiller KA, Hoffer PC, Schmalz G (2015) EDTA conditioning of dentine promotes adhesion, migration and differentiation of dental pulp stem cells. International Endodontic Journal doi: 10.1111/iej.12492. [Epub ahead of print]


Gianluca Gambarini
Universita' degli Studi di Roma, Rome, Italy
Biochemical characterization of dental pulp stem cells and effect of methylacrylate monomers on cell differentiation
Award: 10000 Euros
Publications: Nocca G, Ragno R, Carbone V, Martorana GE, Rossetti DV, Gambarini G, Giardina B, Lupi A. (2011) Identification of glutathione-methacrylates adducts in gingival fibroblasts and erythrocytes by HPLC-MS and capillary electrophoresis. Dental Materials 27,e87-98.
Gambarini G, Plotino G, Grande NM, Nocca G, Lupi A, Giardina B, De Luca M, Testarelli L (2011) In vitro evaluation of the cytotoxicity of FotoSan™ light-activated disinfection on human fibroblasts. Medical Science Monitor 17, MT21-5.
Testarelli L; Nocca G, Lupi A; Pacifici G; Pompa G; Vozza I, Gambarini G (2012) Biocompatibility of root canal filling materials: differences between vitality and functionality tests. European Journal of Inflammation 10, 105-10.
Chronopoulou L, Nocca G, Castagnola M, Paludetti G, Ortaggi G, Sciubba F, Bevilacqua M, Lupi A, Gambarini G, Palocci C (2016) Chitosan based nanoparticles functionalized with peptidomimetic derivatives for oral drug delivery. New Biotechnology 33, 23-31

Suzette van der Waal
Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands
How to disrupt biofilm matrix
Award: 10000 Euros
Publication: van der Waal S V, de Almeida J, Krom B P, de Soet J J, Crielaard W Diffusion of antimicrobials in multispecies biofilms evaluated in a new biofilm model DOI: 10.1111/iej.12634


Maria Elissavet Metska
Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands
Assessment by Cone Beam Computed Tomography of the rate of periapical bone healing after root canal treatment
Award: 10000 Euros
Publication: Metska ME, Parsa A, Aartman IHA, Wesselink PR, Ozok AR Volumetric changes in apical radiolucencies of endodontically treated teeth assessed by cone-beam computed tomography 1 Year after orthograde retreatment Journal of Endodontics 2013:39;1504-9

Bart Huybrechts
Catholic University of Leuven, Leuven, Belgium
Randomized clinical trial to study the biological effect of minimally invasive endodontic treatment protocols in modern dentistry
Award: 10000 Euros


Ashraf ElAyouti
University of Tübingen, Tübingen, Germany
Depletive effect of root canal treatment procedures on the modulus of elasticity of teeth
Award: 5000 Euros
Publications: C. John, C. Löst, A. ElAyouti Ultrasonic monitoring of the effect of sodium hypochlorite on the elasticity of dentine International Endodontic Journal 2013:46;477-482

Andreea Didilescu
Carol Davila University of Medicine and Pharmacy, Bukarest, Romania
Identification by genomic analysis of the pathogenic microflora in combined endo-periodontal lesions
Award: 5000 Euros
Didilescu AC, Rusu D, Anghel A, Nica L, Iliescu A, Greabu M, Bancescu G, Stratul SI (2012) Investigation of six selected bacterial species in endo-periodontal lesions. International Endodontic Journal, 45, 282–293,
Didilescu AC, Rusu D, Greabu M, Iliescu AA, Bancescu G, Anghel A, Lenghel Florin, Stratul S-I Investigation of five periopathogens in patients with endo-periodontal lesions. Journal de Parodontologie & d'Implantologie Orale 2011;30:107-16


Hagay Shemesh
Do leakage models measure penetration through root fillings or root dentine?
Academic Centre for Dentistry (ACTA), Amsterdam, The Netherlands
Award: 5000 Euros
Shemesh H, van den Bos M, Wu MK, Wesselink PR. Glucose penetration and fluid transport through coronal root structure and filled root canals International Endodontic Journal 2007;40:866-72.

Colin Murray
University of Glasgow, Glasgow, UK
Does photoactivated disinfection (PAD) improve clinical outcomes of root canal re-treatment in vivo and is it effective upon in vitro root canal biofilms?
Award: 5000 Euros 


Maarten Meire
Ghent University Hospital, Gent, Belgium
Evaluation of antimicrobial effectiveness of different laser systems in an infected tooth model
Award: 5000 Euros
Publication: Meire MA, De Prijck K, Coenye T, Nelis HJ, De Moor RJ (2009) Effectiveness of different laser systems to kill Enterococcus faecalis in aqueous suspension and in an infected tooth model. International Endodontic Journal 42, 351-9.

Alexandra Petersen
J.W. Goethe-University Frankfurt, Germany
Efficacy of different disinfection systems in infected root canals applying molecular techniques (PCR)
Award: 5000 Euros


Luis Chávez de Paz
The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden
Studies on bacteria remaining in root canals of teeth with apical periodontitis undergoing treatment
Award: 5000 Euros
Chávez de Paz LE, Molander A, Dahlén G. Gram-positive rods prevailing in teeth with apical periodontitis undergoing root canal treatment. International Endodontic Journal 2004;37;579-87.
Chávez de Paz L, Svensäter G, Dahlén G, Bergenholtz G. Streptococci from root canals in teeth with apical periodontitis receiving endodontic treatment. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology 2005;100: 232-41.
Chávez de Paz LE, Bergenholtz G, Dahlén G, Svensäter G. Response to alkaline stress by root canal bacteria in biofilms. International Endodontic Journal 2007;40:344-55.

Stephane Simon
U.F.R. d’Odontologie, Paris, France
Implementation of laboratory model for studying pulpal response in the transgenic mouse. Application to the use of Mineral Trioxide Aggregate
Award: 5000 Euros
Publication: Simon S, Cooper P, Smith A, et al. Evaluation of a new laboratory model for pulp healing: preliminary study. International Endodontic Journal 2008;41:781-90.


Simon Killough
Queens’s University Belfast, Belfast, Northern Ireland
Development of a biological approach to reparative dentine formation
Award: 5000 Euros

Helena Olsson (Fransson)
University of Malmö, Malmö, Sweden
On the formation of a hard tissue barrier after dental pulp capping in humans
Award: 2000 Euros
Publication: Fransson H, Petersson K, Davies J R. Dentine sialoprotein and collagen I expression after experimental pulp capping in humans using Emdogain®Gel. International Endodontic Journal 2011; 44: 259–267.
The results were also part of a doctoral thesis: Fransson H. On the repair of the dentine barrier.


Leo Tjäderhane
Helsinki, Finland
The role of matrix metalloproteinases (MMPs) in the initiation and progression of pulp necrosis and periapical lesion formation.
Award: 5000 Euros
Publication: Tjäderhane L, Hotakainen T, Kinnunen S, Ahonen M, Salo T. The effect of chemical inhibition of matrix metalloproteinases on the size of experimentally induced apical periodontitis. International Endodontic Journal 2007;40:282-9.

Tracy Krage
University of Düsseldorf, Düsseldorf, Germany 
Angiogenesis and pulpal regeneration in the NOS-3 knockout mouse.
Award: 5000 Euros


Anna Macnish
Guys Hospital, London, UK
Detection of bacteria associated with infectious endocarditis in infected root canals by polymerase chain reaction
Award: 1500 Swiss Francs

Lise-Lotte Nielsen (Kirkevang)
Periapical status in the Danish population
Award: 1000 Swiss Francs
Kirkevang L-L, Ørstavik D, Hörsted-Bindslev P, Wenzel A. Periapical status and quality of root fillings and coronal restorations in a Danish population. International Endodontic Journal 2000;33:509-15.
Kirkevang L-L, Hörsted-Bindslev P, Ørstavik D, Wenzel A. Frequency and distribution of endodontically treated teeth and apical periodontitis in an urban Danish population. International Endodontic Journal 2001;34:198-205.
Kirkevang L-L, Hörsted-Bindslev P, Ørstavik D, Wenzel A. A comparison of the quality of root canal treatment in two Danish sub-populations examined in 1974-75 and 1997-98. International Endodontic Journal 2001;34:607-12.
Kirkevang L-L, Wenzel A. Risk indicators of apical periodontitis. Community Dentistry and Oral Epidemiology 2003;31:59-67.


Zvi Fuss
Award: 2000 Swiss Francs   

Neil Meredith and Kishor Gulabivala
Electrical impedance measurements of root canal length
Award: 1500 Swiss Francs   
Publication: Meredith N, Gulabivala K. Electrical impedance measurements of root canal length Endodontics and Dental Traumatology 1997 Jun;13(3):126-31.

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